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62Mature4young 62M
252 posts
10/20/2021 4:31 pm

I had covid last winter--and was over and done with it in two weeks....pissed me off, really--ruined a 30+ year streak of never being ill... so now I'm immune to covid--I caught it from a masker in church, no less--I do not wear a mask nor have I or will I be vax'd

My immune system trumps the vax at least 13 times over.......and I am now a pure-blood human being


kinkykandm694U 64M/52F  
1 post
10/20/2021 4:34 pm

Recommendation
There is insufficient evidence for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.
Rationale
Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in cell cultures.13 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.14,15 Even though ivermectin appears to accumulate in the lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) against SARS-CoV-2 in vitro.16-19 Subcutaneous administration of ivermectin 400 µg/kg had no effect on SARS-CoV-2 viral loads in hamsters. However, there was a reduction in olfactory deficit (measured using a food-finding test) and a reduction in the interleukin (I-6L-10 ratio in lung tissues.20

Since the last revision of this section of the Guidelines, the results of several randomized trials and retrospective cohort studies of ivermectin use in patients with COVID-19 have been published in peer-reviewed journals or have been made available as manuscripts ahead of peer review. Some clinical studies showed no benefits or worsening of disease after ivermectin use,21-24 whereas others reported shorter time to resolution of disease manifestations that were attributed to COVID-19,25-27 greater reduction in inflammatory marker levels,26 shorter time to viral clearance,21 or lower mortality rates in patients who received ivermectin than in patients who received comparator drugs or placebo.21,27

However, most of these studies had incomplete information and significant methodological limitations, which make it difficult to exclude common causes of bias. These limitations include:

The sample size of most of the trials was small.
Various doses and schedules of ivermectin were used.
Some of the randomized controlled trials were open-label studies in which neither the participants nor the investigators were blinded to the treatment arms.
Patients received various concomitant medications (e.g., doxycycline, hydroxychloroquine, azithromycin, zinc, corticosteroids) in addition to ivermectin or the comparator drug. This confounded the assessment of the efficacy or safety of ivermectin.
The severity of COVID-19 in the study participants was not always well described.
The study outcome measures were not always clearly defined.
Table 2c includes summaries of key studies. Because most of these studies have significant limitations, the Panel cannot draw definitive conclusions on the clinical efficacy of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide further guidance on the role of ivermectin in the treatment of COVID-19.


rh1972 49M  
606 posts
10/20/2021 4:59 pm

(Watch out now! All the virtue signalers are going to see this and get upset! )


NorthEastSAGuy 55M
2 posts
10/20/2021 5:13 pm

https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/

..."Recommendation

There is insufficient evidence for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.


ltrskr 73M  
5073 posts
10/20/2021 5:24 pm

Ivermectin has been used many, many years by farmers and ranchers! AMD quacks won't allow it because of the money it would cost them in their scam sales!


OldStandardDudeX 69M  
121 posts
10/20/2021 5:48 pm

So, which of these treatments are you taking in response to the Covid infection?.....my guess is none....you just use this rant as another way of poking at those you don't agree with, like you have some vast insight into the motivations of those you who speak up against you.

And to feel you have to do this on a sex hook-up / dating site really shows the sad little life you must lead.

But hey, whatever.....


bmsf27 63M  
19 posts
10/20/2021 6:17 pm

Good,you did your research. Now watch out that you are not labeled a wacko,we aren't supposed to know some of this.


Bourre2020 58M

10/20/2021 6:31 pm

Here is the NIH page for Ivermectin and COVID19. Don't just believe what somebody posts on Social Media or a sex site!

https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/

An excerpt:
Recommendation

There is insufficient evidence for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.


New2Midlo 52M  
1037 posts
10/21/2021 9:55 am

So, Merck must be all over this, right? Not so much.
When the manufacturer of a drug says don't use it, I'd tend to listen to them.

Merck (NYSE: MRK), known as MSD outside the United States and Canada, today affirmed its position regarding use of ivermectin during the COVID-19 pandemic. Company scientists continue to carefully examine the findings of all available and emerging studies of ivermectin for the treatment of COVID-19 for evidence of efficacy and safety. It is important to note that, to-date, our analysis has identified:

No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies;
No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and;
A concerning lack of safety data in the majority of studies.
We do not believe that the data available support the safety and efficacy of ivermectin beyond the doses and populations indicated in the regulatory agency-approved prescribing information.


NorthEastSAGuy 55M
2 posts
10/22/2021 4:00 pm

The CDC website DOES NOT recommend ivermectin for a possible treatment for covid-19. The CDC says none of the studies so far have scientific credibility - nothing to do with conspiracy theories, everything to do with scientific method as applied to testing the treatment.

Your title is misleading.


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